Arno G Siraki Selected Research

Antipsychotic Agents (Antipsychotics)

1/2022

Neutrophil Myeloperoxidase-Mediated N-Demethylation of Quetiapine Leads to N-Desalkylquetiapine, a Pharmacologically Active Cytochrome P450 Metabolite.

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Arno G Siraki Research Topics

Disease

7	Leukemia 09/2019 - 07/2007
6	Agranulocytosis (Granulocytopenia) 01/2022 - 07/2007
4	Drug-Related Side Effects and Adverse Reactions 03/2024 - 08/2005
3	Tuberculosis (Tuberculoses) 05/2019 - 04/2016
3	Neoplasms (Cancer) 01/2019 - 11/2012
2	Inflammation (Inflammations) 10/2021 - 02/2007
2	Granuloma 12/2019 - 04/2016
2	Necrosis 12/2019 - 01/2016
2	Infections 04/2016 - 02/2007
2	Peritonitis 03/2016 - 08/2005
2	Hepatocellular Carcinoma (Hepatoma) 10/2013 - 11/2012
2	Neurodegenerative Diseases (Neurodegenerative Disease) 08/2005 - 08/2002
1	Neutropenia 01/2022
1	Latent Tuberculosis 12/2019
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2018
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 01/2018
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 10/2017
1	Cardiomegaly (Heart Hypertrophy) 05/2017
1	Edema (Dropsy) 03/2016
1	Tachycardia (Tachyarrhythmias) 05/2008
1	Breast Neoplasms (Breast Cancer) 07/2007
1	Brain Ischemia (Cerebral Ischemia) 08/2005
1	Hypertension (High Blood Pressure) 08/2005
1	Hypersensitivity (Allergy) 08/2005
1	Liver Diseases (Liver Disease) 08/2005
1	Pain (Aches) 02/2005
1	Carcinogenesis 08/2002

Drug/Important Bio-Agent (IBA)

7	Peroxidase (Myeloperoxidase)IBA 10/2021 - 07/2007
4	EnzymesIBA 03/2024 - 11/2012
4	Isoniazid (Ftivazide)FDA LinkGeneric 12/2019 - 01/2016
4	Proteins (Proteins, Gene)FDA Link 11/2012 - 07/2007
3	Aminoglutethimide (Cytadren)FDA Link 09/2015 - 07/2007
3	AminesIBA 07/2011 - 08/2002
3	Free RadicalsIBA 05/2010 - 07/2007
2	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 03/2024 - 05/2017
2	quinone (benzoquinone)IBA 08/2021 - 11/2012
2	NAD (NADH)IBA 05/2019 - 11/2012
2	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/2017 - 02/2005
2	CationsIBA 12/2013 - 08/2002
2	Oxidoreductases (Dehydrogenase)IBA 11/2012 - 08/2002
1	CytochromesIBA 03/2024
1	Heme (Haem)IBA 03/2024
1	Mixed Function Oxygenases (Monooxygenases)IBA 03/2024
1	Clozapine (Clozaril)FDA LinkGeneric 01/2022
1	Quetiapine Fumarate (Seroquel)FDA Link 01/2022
1	Antipsychotic Agents (Antipsychotics)IBA 01/2022
1	Biomarkers (Surrogate Marker)IBA 10/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 08/2021
1	NRH - quinone oxidoreductase2IBA 08/2021
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2019
1	Culture MediaIBA 09/2019
1	LigandsIBA 01/2019
1	2-MethoxyestradiolIBA 01/2018
1	Drinking WaterIBA 01/2018
1	Matrix Metalloproteinases (MMPs)IBA 10/2017
1	Trypan Blue FDA Link 10/2017
1	Adenosine Triphosphate (ATP)IBA 10/2017
1	AcidsIBA 05/2017
1	Hydroxyeicosatetraenoic Acids (HETE)IBA 05/2017
1	Isoproterenol (Isoprenaline)FDA LinkGeneric 05/2017
1	Superoxides (Superoxide)IBA 05/2017
1	Mitogen-Activated Protein KinasesIBA 05/2017
1	isonicotinyl-NADIBA 04/2016
1	Anti-Inflammatory Agents (Anti-Inflammatories)IBA 03/2016
1	CarrageenanIBA 03/2016
1	Glucose OxidaseIBA 01/2016
1	Pentetic Acid (DTPA)FDA LinkGeneric 12/2013
1	CarbonIBA 12/2013
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 10/2013
1	Vitamin K 3 (Menadione)FDA Link 10/2013
1	Messenger RNA (mRNA)IBA 11/2012
1	Procainamide (Procan)FDA LinkGeneric 05/2008
1	AcecainideIBA 05/2008
1	Estrogens (Estrogen)FDA Link 07/2007
1	Aromatase InhibitorsIBA 07/2007
1	Hypochlorous Acid (Hypochlorite)IBA 02/2007
1	HaptensIBA 08/2005
1	AldehydesIBA 08/2005
1	Biogenic Amines (Biogenic Amine)IBA 08/2002

Therapy/Procedure

1	Immunotherapy 01/2019
1	Therapeutics 10/2017
1	Chemoprevention 11/2012